Revisión bibliográfica: diabetes tipo II y dietas bajas en carbohidratos

Autores/as

DOI:

https://doi.org/10.71112/ay97p156

Palabras clave:

Diabetes mellitus tipo 2, dietas bajas en carbohidratos, control glucémico, control metabólico, nutrición terapéutica

Resumen

La diabetes mellitus tipo 2 (DM2) es una enfermedad metabólica crónica caracterizada por hiperglucemia, originada por resistencia a la insulina y disfunción de las células beta pancreáticas. En los últimos años, las dietas bajas en carbohidratos (DBC) han ganado popularidad como estrategia para mejorar el control glucémico y metabólico en la DM2. Esta revisión analiza estudios recientes (2020-2025) que evalúan su eficacia y seguridad. Los hallazgos muestran mejoras significativas en el control glucémico, reducción de peso y optimización del perfil lipídico. No obstante, factores como la adherencia al régimen y la calidad de las grasas consumidas requieren atención para prevenir efectos adversos y mantener beneficios a largo plazo. En conclusión, las DBC representan una alternativa viable dentro del tratamiento integral de la DM2, siempre aplicadas con supervisión profesional, ajustando según las necesidades del paciente para garantizar resultados sostenibles y seguros.

Descargas

Los datos de descarga aún no están disponibles.

Referencias

ADA Standards of Care (2025) — Glycemic Goals and Hypoglycemia. Diabetes Care, 48 (Suplemento_1): S128–S145. https://doi.org/10.2337/dc25-S006

Ahmed, S., Bellamkonda, S., Zilbermint, M., Wang, J., & Kalyani, R. (2020). Effects of the low carbohydrate, high fat diet on glycemic control and body weight in patients with type 2 diabetes: experience from a community-based cohort. BMJ open diabetes research & care, 8(1), e000980. https://doi.org/10.1136/bmjdrc-2019-000980

Akbari, M., Vali, M., Rezaei, S., Bazmi, S., Tabrizi, R., & Lankarani, K. B. (2024). Comparison of weight loss effects among overweight/obese adults: A network meta-analysis of mediterranean, low carbohydrate, and low-fat diets. Clinical nutrition ESPEN, 64, 7–15. https://doi.org/10.1016/j.clnesp.2024.08.023

Anderson Vásquez, Hazel Ester. (2020). ¿Qué dieta seleccionar en el tratamiento de la obesidad?. Anales Venezolanos de Nutrición, 33(1), 41-50. http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0798-07522020000100041&lng=es&tlng=es.

Apekey, T. A., Maynard, M. J., Kittana, M., & Kunutsor, S. K. (2022). Comparison of the Effectiveness of Low Carbohydrate Versus Low Fat Diets, in Type 2 Diabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 14(20), 4391. https://doi.org/10.3390/nu14204391

Barber, T. M., Hanson, P., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2021). The Low-Carbohydrate Diet: Short-Term Metabolic Efficacy Versus Longer-Term Limitations. Nutrients, 13(4), 1187. https://doi.org/10.3390/nu13041187

Beretta, M. V., Flores, C. A. O., Colameo, G. F., Echabe, L. W., & Busnello, F. M. (2025). Low-Carbohydrate Dietary Interventions for Metabolic Control in Individuals With Type 2 Diabetes Mellitus: An Overview of Systematic Reviews. Nutrition reviews, 83(7), e1677–e1692. https://doi.org/10.1093/nutrit/nuae123

Berger, M., Marx, N., & Marx-Schütt, K. (2025). Cardiovascular Risk Reduction in Patients with Type 2 Diabetes: What Does the Cardiologist Need to Know?. European cardiology, 20, e09. https://doi.org/10.15420/ecr.2024.29

Chen, C. Y., Huang, W. S., Ho, M. H., Chang, C. H., Lee, L. T., Chen, H. S., Kang, Y. D., Chie, W. C., Jan, C. F., Wang, W. D., & Tsai, J. S. (2022). The potential prolonged effect at one-year follow-up after 18-month randomized controlled trial of a 90 g/day low-carbohydrate diet in patients with type 2 diabetes. Nutrition & diabetes, 12(1), 17. https://doi.org/10.1038/s41387-022-00193-4

Churuangsuk, C., Lean, M. E. J., & Combet, E. (2020). Low and reduced carbohydrate diets: challenges and opportunities for type 2 diabetes management and prevention. The Proceedings of the Nutrition Society, 1–16. Advance online publication. https://doi.org/10.1017/S0029665120000105

Das, R., Mohammad, N., Islam, M. S., Das, S., Abdullah, F., Kader, M. A., Mamun, M. A. A., Dutta, S., Unwin, D., & Mazak, I. (2025). Long-Term Efficacy and Safety of a Low-Carbohydrate Diet in Type 2 Diabetes Remission: A Systematic Review. Cureus, 17(9), e93340. https://doi.org/10.7759/cureus.93340

Dening, J., Mohebbi, M., Abbott, G., George, E. S., Ball, K., & Islam, S. M. S. (2023). A web-based low carbohydrate diet intervention significantly improves glycaemic control in adults with type 2 diabetes: results of the T2Diet Study randomised controlled trial. Nutrition & diabetes, 13(1), 12. https://doi.org/10.1038/s41387-023-00240-8

Dorans, KS, Bazzano, LA, Qi, L. et al. Ensayo sobre el patrón dietético bajo en carbohidratos y los resultados glucémicos (ADEPT) en personas con hemoglobina A1c elevada: protocolo de estudio para un ensayo controlado aleatorizado. Trials 22 , 108 (2021). https://doi.org/10.1186/s13063-020-05001-x

Goldenberg, J. Z., Day, A., Brinkworth, G. D., Sato, J., Yamada, S., Jönsson, T., Beardsley, J., Johnson, J. A., Thabane, L., & Johnston, B. C. (2021). Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial data. BMJ (Clinical research ed.), 372, m4743. https://doi.org/10.1136/bmj.m4743

Gram-Kampmann, E. et al. (2022). Effects of a 6-month, low-carbohydrate diet on glycaemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes: An open-label randomized controlled trial. Diabetes, Obesity & Metabolism, 24(4), 693–703. https://doi.org/10.1111/dom.14633

Griauzde, D. H., Ling, G., Wray, D., DeJonckheere, M., Mizokami Stout, K., Saslow, L. R., Fenske, J., Serlin, D., Stonebraker, S., Nisha, T., Barry, C., Pop-Busui, R., Sen, A., & Richardson, C. R. (2022). Continuous Glucose Monitoring With Low-Carbohydrate Nutritional Coaching to Improve Type 2 Diabetes Control: Randomized Quality Improvement Program. Journal of medical Internet research, 24(2), e31184. https://doi.org/10.2196/31184

Hironaka, J., Hamaguchi, M., Ichikawa, T., Nakajima, H., Okamura, T., Majima, S., Senmaru, T., Okada, H., Ushigome, E., Nakanishi, N., Joo, E., Shide, K., & Fukui, M. (2024). Low-carbohydrate diets in East Asians with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. Journal of diabetes investigation, 15(12), 1753–1762. https://doi.org/10.1111/jdi.14326

Ichikawa, T., Okada, H., Hironaka, J., Nakajima, H., Okamura, T., Majima, S., Senmaru, T., Ushigome, E., Nakanishi, N., Hamaguchi, M., Joo, E., Shide, K., & Fukui, M. (2024). Efficacy of long-term low carbohydrate diets for patients with type 2 diabetes: A systematic review and meta-analysis. Journal of diabetes investigation, 15(10), 1410–1421. https://doi.org/10.1111/jdi.14271

International Diabetes Federation. (2025, abril 7). Over 250 million people worldwide unaware they have diabetes, according to new IDF research. https://idf.org/news/idf-diabetes-atlas-11th-edition/

Jerez, C., Medina, Y., Ortiz A., González, S., & Aguirre , M. C . (2022). Fisiopatología y alteraciones clínicas de la diabetes mellitus tipo 2: revisión de literatura. Revista Nova publicación científica En Ciencias biomédicas, 20(38), 65-103. https://doi.org/10.22490/24629448.6184

Jing, T., Zhang, S., Bai, M., Chen, Z., Gao, S., Li, S., & Zhang, J. (2023). Effect of Dietary Approaches on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review with Network Meta-Analysis of Randomized Trials. Nutrients, 15(14), 3156. https://doi.org/10.3390/nu15143156

Jooste, B. R., Kolivas, D., Brukner, P., & Moschonis, G. (2023). Effectiveness of Technology-Enabled, Low Carbohydrate Dietary Interventions, in the Prevention or Treatment of Type 2 Diabetes Mellitus in Adults: A Systematic Literature Review of Randomised Controlled and Non-Randomised Trials. Nutrients, 15(20), 4362. https://doi.org/10.3390/nu15204362

Kelly, T., Unwin, D., & Finucane, F. (2020). Low-Carbohydrate Diets in the Management of Obesity and Type 2 Diabetes: A Review from Clinicians Using the Approach in Practice. International journal of environmental research and public health, 17(7), 2557. https://doi.org/10.3390/ijerph17072557

Kumar, N., Merrill, J., Carlson, S., German, J., & Yancy, W., Jr (2022). Adherence to Low-Carbohydrate Diets in Patients with Diabetes: A Narrative Review. Diabetes, metabolic syndrome and obesity : targets and therapy, 15, 477–498. https://doi.org/10.2147/DMSO.S292742

Lan, J., Chen, M., Zhang, X., & Yang, J. (2025). Effect of dietary carbohydrate intake on glycaemic control and insulin resistance in type 2 diabetes: A systematic review and meta-analysis. Asia Pacific journal of clinical nutrition, 34(3), 282–297.https://doi.org/10.6133/apjcn.202506_34(3).0003

Landry, M. J., Crimarco, A., & Gardner, C. D. (2021). Benefits of Low Carbohydrate Diets: a Settled Question or Still Controversial?. Current obesity reports, 10(3), 409–422. https://doi.org/10.1007/s13679-021-00451-z

Li, S., Ding, L., & Xiao, X. (2021). Comparing the Efficacy and Safety of Low-Carbohydrate Diets with Low-Fat Diets for Type 2 Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. International journal of endocrinology, 2021, 8521756. https://doi.org/10.1155/2021/8521756

Liu, B., Hu, Y., Rai, S. K., Wang, M., Hu, F. B., & Sun, Q. (2023). Low-Carbohydrate Diet Macronutrient Quality and Weight Change. JAMA network open, 6(12), e2349552. https://doi.org/10.1001/jamanetworkopen.2023.49552

Maldonado-Celis ME. Diabetes mellitus tipo 2 y alimentación sostenible. Salud UIS. 2025; 57: e25v57r02. doi: https://doi.org/10.18273/saluduis.57.e:25v57r02

Mongkolsucharitkul, P., Surawit, A., Pimsen, A., Winitchayothin, S., Pumeiam, S., Pinsawas, B., Ophakas, S., Suta, S., Pasookhush, P., & Mayurasakorn, K. (2025). Effectiveness of low-carbohydrate diets on type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials in Eastern vs. Western populations. Diabetes Research and Clinical Practice, 229, 112464. https://doi.org/10.1016/j.diabres.2025.112464

Morris E , Aveyard P. Dyson P , Noreik M. ,Bailey C. , Fox R. ,Jerome D, Tan G. , Jebb S. (2020) A food-based, low-energy, low-carbohydrate diet for people with type 2 diabetes in primary care: A randomized controlled feasibility trial . Diabetes Obes Metab . 2020; 22 : 512-520 . https://doi.org/10.1111/dom.13915.

Nicholas, A., Soto, A., Lambert, H., & Collins, A. L. (2021). Restricting carbohydrates and calories in the treatment of type 2 diabetes: a systematic review of the effectiveness of 'low-carbohydrate' interventions with differing energy levels. Journal of nutritional science, 10, e76. https://doi.org/10.1017/jns.2021.67

Ojo, O., Ojo, OO, Onilude, Y., Apau, V., Kazangarare, I., Arogundade, T. y Brooke, J. (2025). Avances actuales y perspectivas futuras en el uso de una dieta baja en carbohidratos para el manejo de personas con diabetes tipo 2: Una revisión sistemática de ensayos controlados aleatorizados. Revista Internacional de Investigación Ambiental y Salud Pública, 22 (9), 1352. https://doi.org/10.3390/ijerph22091352

Pavlidou, E., Papadopoulou, S, Fasoulas, A., Mantzorou, M. y Giaginis, C. (2023). Evidencia clínica de dietas bajas en carbohidratos contra la obesidad y la diabetes mellitus. Metabolitos, 13 (2), 240. https://doi.org/10.3390/metabo13020240

Revé , L., Alvarez, J., Suárez, D., Torres, M., Delisle, A., & Fuentes, Y. (2022). Morbilidad oculta de diabetes mellitus en población de riesgo. Acta Médica del Centro, 16(4), 693-703. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S2709-79272022000400693&lng=es&tlng=es.

Silverii, G., Botarelli, L., Dicembrini, I., Girolamo, V., Santagiuliana, F., Monami, M., & Mannucci, E. (2020). Low-carbohydrate diets and type 2 diabetes treatment: a meta-analysis of randomized controlled trials. Acta diabetológica, 57(11), 1375–1382. https://doi.org/10.1007/s00592-020-01568-8

Teicholz, N., Croft, S., Cuaranta, I., Cucuzzella, M., Glandt, M., Griauzde, D, Jerome-Zapadka, K., Kalayjian, T., Murphy, K., Nelson, M., Shanahan, C., Nishida, J., Oh, R., Parrella, N., Saner, E, Sethi, S., Volek, J, Williden, M. y Wolver, S. (2025). Mitos y realidades sobre las dietas bajas en carbohidratos. Nutrientes , 17 (6), 1047. https://doi.org/10.3390/nu17061047

Thomsen, M., Skytte, M., Samkani, A., Astrup, A., Fenger, M., Frystyk, J., Hartmann, B., Holst, J., Larsen, T., Madsbad, S., Magkos, F., Rehfeld, J. F., Haugaard, S. B., & Krarup, T. (2022). Weight loss improves β-cell function independently of dietary carbohydrate restriction in people with type 2 diabetes: A 6-week randomized controlled trial. Frontiers in nutrition, 9, 933118. https://doi.org/10.3389/fnut.2022.933118

Tian W., Cao S., Guan Y., Zhang Z., Liu Q., Ju J., Xi R., Bai, R. (2024). The effects of low-carbohydrate diet on glucose and lipid metabolism in overweight or obese patients with T2DM: A meta-analysis of randomized controlled trials. Frontiers in Nutrition, 11, 1516086. https://doi.org/10.3389/fnut.2024.1516086

Volek ,J. , Yancy W. , Gower B. , Phinney S. , Slavin J., Koutnik A. , Hurn M. , Spinner J., Cucuzzella M., Hecht F., J. et al., (2024). Expert consensus on nutrition and lower-carbohydrate diets: An evidence- and equity-based approach to dietary guidance. Frontiers in Nutrition, 11, 1376098. https://doi.org/10.3389/fnut.2024.1376098

Weber, P., Thomsen, M., Skytte, M., Samkani, A., Carl, M., Astrup, A., Frystyk, J., Holst, J., Hartmann, B., Madsbad, S., Magkos, F., Krarup, T., & Haugaard, S. (2022). Effects of Carbohydrate Restriction on Body Weight and Glycemic Control in Individuals with Type 2 Diabetes: A Randomized Controlled Trial of Efficacy in Real-Life Settings. Nutrients, 14(24), 5244. https://doi.org/10.3390/nu14245244

Yan, Y., Asemani, S., Jamilian, P., & Yang, C. (2025). The efficacy of low-carbohydrate diets on glycemic control in type 2 diabetes: a comprehensive overview of meta-analyses of controlled clinical trials. Diabetology & metabolic syndrome, 17(1), 341. https://doi.org/10.1186/s13098-025-01890-7

Yang, Z., Mi, J., Wang, Y., Xue, L., Liu, J., Fan, M., Zhang, D., Wang, L., Qian, H., & Li, Y. (2021). Effects of low-carbohydrate diet and ketogenic diet on glucose and lipid metabolism in type 2 diabetic mice. Nutrition (Burbank, Los Angeles County, Calif.), 89, 111230. https://doi.org/10.1016/j.nut.2021.111230

Publicado

2025-10-31

Número

Sección

Ciencias de la Salud

Cómo citar

Loor Santos, G. G., & Anderson Vásquez, H. E. (2025). Revisión bibliográfica: diabetes tipo II y dietas bajas en carbohidratos. Revista Multidisciplinar Epistemología De Las Ciencias, 2(4), 755-776. https://doi.org/10.71112/ay97p156